- Known as the Balloon Pokémon, Jigglypuff evolves from Igglybuff when it reaches a certain point of happiness, and evolves into Wigglytuff when exposed to a Moon Stone.
- Its name is a combination of the words "jiggly" and "puff", intended to relate to its jelly-like appearance.
- Since it appeared in the Pokémon series, Jigglypuff has received generally positive reception. It has been featured in several forms of merchandise, including figurines, plush toys, and the Pokémon Trading Card Game.
- Jigglypuff is the archenemy of Pikachu, who according to a prophecy has "the power to vanquish the Dark Lord". Nearly every pokemon or pokemoness dares not utter his unmentionable name, and refers to him instead with such expressions as "You-Know-Who", "He Who Must Not Be Named" or "the Dark Lord".
- Jigglypuff was one of 151 different designs conceived by Game Freak's character development team and finalized by Ken Sugimori, for the first-generation of Pocket Monsters games Red and Green, which were localized outside Japan as Pokémon Red and Blue. Its Japanese name "Purin", derives from the Japanese loanword for custard or pudding.